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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2252


    Title: Caspase 3, periodically expressed and activated at G2/M transition, is required for nocodazole-induced mitotic checkpoint
    Authors: Hsu, SL;Yu, CTR;Yin, SC;Tang, MJ;Tien, AC;Wu, YM;Huang, CYF
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: Caspases have been known for several years for their involvement in executing apoptosis, where unwanted or damaged cells are eliminated. Surprisingly, after analysis of the relevant data set from the Stanford microarray database, we noticed that the gene expression pattern for caspase 3, but not for caspase 1, 6, 7, 8, 9, or 10, undergoes periodic change in the HeLa cell cycle. In this study, we have demonstrated that caspase 3, but not other caspases, is upregulated and activated just prior to mitosis. Pretreatment of human hepatoma cells with a caspase 3 inhibitor z-DEVD-FMK, prior to the treatment with an antimicrotubule drug nocodazole, abrogates the mitotic arrest, suggesting that caspase 3 (or a caspase 3-like enzyme) might be involved in mitotic-spindle checkpoint. The studies not only characterize caspase 3 as a cell cycle-regulated protein, but also link the protein to nocodazole-dependent mitotic checkpoint, greatly expanding the understanding of caspase 3.
    Keywords: Biochemistry & Molecular Biology;Cell Biology
    Date: 2006-05
    Relation: Apoptosis. 2006 May;11(5):765-771.
    Link to: http://dx.doi.org/10.1007/s10495-006-5880-x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1360-8185&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000238154000010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33745032590
    Appears in Collections:[黃奇英(1998-2005)] 期刊論文

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