國家衛生研究院 NHRI:Item 3990099045/2252
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    題名: Caspase 3, periodically expressed and activated at G2/M transition, is required for nocodazole-induced mitotic checkpoint
    作者: Hsu, SL;Yu, CTR;Yin, SC;Tang, MJ;Tien, AC;Wu, YM;Huang, CYF
    貢獻者: Division of Molecular and Genomic Medicine
    摘要: Caspases have been known for several years for their involvement in executing apoptosis, where unwanted or damaged cells are eliminated. Surprisingly, after analysis of the relevant data set from the Stanford microarray database, we noticed that the gene expression pattern for caspase 3, but not for caspase 1, 6, 7, 8, 9, or 10, undergoes periodic change in the HeLa cell cycle. In this study, we have demonstrated that caspase 3, but not other caspases, is upregulated and activated just prior to mitosis. Pretreatment of human hepatoma cells with a caspase 3 inhibitor z-DEVD-FMK, prior to the treatment with an antimicrotubule drug nocodazole, abrogates the mitotic arrest, suggesting that caspase 3 (or a caspase 3-like enzyme) might be involved in mitotic-spindle checkpoint. The studies not only characterize caspase 3 as a cell cycle-regulated protein, but also link the protein to nocodazole-dependent mitotic checkpoint, greatly expanding the understanding of caspase 3.
    關鍵詞: Biochemistry & Molecular Biology;Cell Biology
    日期: 2006-05
    關聯: Apoptosis. 2006 May;11(5):765-771.
    Link to: http://dx.doi.org/10.1007/s10495-006-5880-x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1360-8185&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000238154000010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33745032590
    顯示於類別:[黃奇英(1998-2005)] 期刊論文

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