國家衛生研究院 NHRI:Item 3990099045/2255

NHRI > Institute of Molecular and Genomic Medicine > Chi-Ying F. Huang(1998-2005) > Periodical Articles > Item 3990099045/2255

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2255

Title:	Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer
Authors:	Tseng, YS;Tzeng, CC;Huang, CYF;Chen, PH;Chiu, AWH;Hsu, PY;Huang, GC;Wang, YC;Liu, HS
Contributors:	Division of Molecular and Genomic Medicine
Abstract:	Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Keywords:	Oncology
Date:	2006-09-08
Relation:	Cancer Letters. 2006 Sep;241(1):93-101.
Link to:	http://dx.doi.org/10.1016/j.canlet.2005.10.014
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3835&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000240712200012
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=39049177016
Appears in Collections:	[Chi-Ying F. Huang(1998-2005)] Periodical Articles

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