國家衛生研究院 NHRI:Item 3990099045/2265
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    題名: Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma
    作者: Tsou, AP;Yang, CW;Huang, CYF;Yu, RCT;Lee, YCG;Chang, CW;Chen, BR;Chung, YF;Fann, MJ;Chi, CW;Chiu, JH;Chou, CK
    貢獻者: Division of Molecular and Genomic Medicine
    摘要: An analytic strategy was followed to identify putative regulatory genes during the development of human hepatocellular carcinoma (HCC). This strategy employed a bioinformatics analysis that used a database search to identify genes, which are differentially expressed in human HCC and are also under cell cycle regulation. A novel cell cycle regulated gene (HURP) that is overexpressed in HCC was identified. Full-length cDNAs encoding the human and mouse HURP genes were isolated. They share 72 and 61% identity at the nucleotide level and amino-acid level, respectively. Endogenous levels of HURP mRNA were found to be tightly regulated during cell cycle progression as illustrated by its elevated expression in the G(2)/M phase of synchronized HeLa cells and in regenerating mouse liver after partial hepatectomy. Immunofluorescence studies revealed that hepatoma up-regulated protein (HURP) localizes to the spindle poles during mitosis. Overexpression of HURP in 293T cells resulted in an enhanced cell growth at low serum levels and at polyhema-based, anchorage-independent growth assay. Taken together, these results strongly suggest that HURP is a potential novel cell cycle regulator that may play a role in the carcinogenesis of human cancer cells.
    關鍵詞: Biochemistry & Molecular Biology;Oncology;Cell Biology;Genetics & Heredity
    日期: 2003-01-16
    關聯: Oncogene. 2003 Jan;22(2):298-307.
    Link to: http://dx.doi.org/10.1038/sj.onc.1206129
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-9232&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000180322400015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037448686
    顯示於類別:[黃奇英(1998-2005)] 期刊論文

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