國家衛生研究院 NHRI:Item 3990099045/2266
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    题名: Collapsin response mediator protein-1: A novel invasion-suppressor gene
    作者: Shih, JY;Lee, YCG;Yang, SC;Hong, TM;Huang, CYF;Yang, PC
    贡献者: Division of Molecular and Genomic Medicine
    摘要: Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-1 inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-1 mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.
    关键词: Oncology
    日期: 2003
    關聯: Clinical and Experimental Metastasis. 2003;20(1):69-76.
    Link to: http://dx.doi.org/10.1023/A:1022598604565
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0262-0898&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000181128900010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037219922
    显示于类别:[黃奇英(1998-2005)] 期刊論文

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