國家衛生研究院 NHRI:Item 3990099045/2272
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    題名: Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3
    作者: Lee, WS;Hsu, CY;Wang, PL;Huang, CYF;Chang, CH;Yuan, CJ
    貢獻者: Division of Molecular and Genomic Medicine
    摘要: Mst3, a human Ste20-like protein kinase, has been recently demonstrated to undergo a caspase-mediated cleavage during apoptosis. The proteolytic cleavage of the C-terminus of Mst3 caused nuclear translocation of its kinase domain. This work provides evidence that Mst3 may contain a bipartite-like nuclear localization sequence (NLS) at the C-terminus of its kinase domain (residues 278-292). The removal of NLS from the kinase domain of Mst3 led to the cytoplasmic accumulation of EGFP-Mst3 (Delta277). The presence of nuclear exporting signals in the Mst3 was also demonstrated by leptomycin B-treatment and serial deletion of the C-terminal regulatory domain of Mst3. A nuclear export signal was also postulated to be in the regions of amino acids 335-386. In conclusion, Mst3 contains both NLS and NES signals, which may cooperate to control the subcellular distribution of Mst3.
    關鍵詞: Biochemistry & Molecular Biology;Biophysics;Cell Biology
    日期: 2004-08-13
    關聯: FEBS Letters. 2004 Aug;572(1-3):41-45.
    Link to: http://dx.doi.org/10.1016/j.febslet.2004.07.007
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-5793&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000223519300009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=4143118028
    顯示於類別:[黃奇英(1998-2005)] 期刊論文

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