國家衛生研究院 NHRI:Item 3990099045/2301
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2301


    Title: No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis
    Authors: Chang, YT;Lee, WR;Yu, CW;Liu, HN;Lin, MW;Huang, CH;Chen, CC;Lee, DD;Wang, WJ;Hu, CH;Tsai, SF
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4, -10, -12B and -13, the IL-4 receptor, tumour necrosis factor (TNF)-alpha, STAT6, and interferon (IFN)-alpha. Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that the analysed genetic polymorphisms of cytokine genes do not appear to be associated with AD susceptibility in our Chinese population.
    Keywords: Dermatology
    Date: 2006-05
    Relation: Clinical and Experimental Dermatology. 2006 May;31(3):419-423.
    Link to: http://dx.doi.org/10.1111/j.1365-2230.2006.02124.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0307-6938&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000236242400024
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33645334935
    Appears in Collections:[Shih-Feng Tsai] Periodical Articles

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