國家衛生研究院 NHRI:Item 3990099045/2323
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    題名: Comparative genome analysis of Vibrio vulnificus, a marine pathogen
    作者: Chen, CY;Wu, KM;Chang, YC;Chang, CH;Tsai, HC;Liao, TL;Liu, YM;Chen, HJ;Shen, ABT;Li, JC;Su, TL;Shao, CP;Lee, CT;Hor, LI;Tsai, SF
    貢獻者: Division of Molecular and Genomic Medicine
    摘要: The halophile Vibrio vulnificus is an etiologic agent of human mortality from seafood-borne infections. We applied whole-genome sequencing and comparative analysis to investigate the evolution of this pathogen. The genome of biotype I strain, V. vulniflicus YJ016, was sequenced and includes two chromosomes of estimated 3377 kbp and 1857 kbp in size, and a plasmid-of 48,508 bp. A super-integron (SI) was identified, and the SI region spans 139 kbp and contains 188 gene cassettes. In contrast to non-SI sequences, the captured gene cassettes are unique for any given Vibrio species and are highly variable among V. vulnificus strains. Multiple rearrangements were found when comparing the 5.3-Mbp V. vulnificus YJ016 genome and the 4.0-Mbp V. cholerae El Tor N16961 genome. The organization of gene clusters of capsular polysaccharide, iron metabolism, and RTX toxin showed distinct genetic features of V Vulnificus and V. cholerae. The content of the V vulnificus genome contained gene duplications and evidence of horizontal transfer, allowing for genetic diversity and function in the marine environment. The genomic information obtained in this study can be applied to monitoring vibrio infections and identifying virulence genes in V vulnificus.
    關鍵詞: Biochemistry & Molecular Biology;Biotechnology & Applied Microbiology;Genetics & Heredity
    日期: 2003-12
    關聯: Genome Research. 2003 Dec;13(12):2577-2587.
    Link to: http://dx.doi.org/10.1101/gr.1295503
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1088-9051&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000186920200007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=10744231052
    顯示於類別:[蔡世峯] 期刊論文

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