國家衛生研究院 NHRI:Item 3990099045/2336
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    题名: Quantitative proteomic analysis of metabolic regulation by copper ions in Methylococcus capsulatus (Bath)
    作者: Kao, WC;Chen, YR;Yi, EC;Lee, H;Tian, Q;Wu, KM;Tsai, SF;Yu, SSF;Chen, YJ;Aebersold, R;Chan, SI
    贡献者: Division of Molecular and Genomic Medicine
    摘要: Copper ions switch the oxidation of methane by soluble methane monooxygenase to particulate methane monooxygenase in Methylococcus capsulatus ( Bath). Toward understanding the change in cellular metabolism related to this transcriptional and metabolic switch, we have undertaken genomic sequencing and quantitative comparative analysis of the proteome in M. capsulatus ( Bath) grown under different copper-to-biomass ratios by cleavable isotope-coded affinity tag technology. Of the 682 proteins identified, the expressions of 60 proteins were stimulated by at least 2-fold by copper ions; 68 proteins were down-regulated by 2-fold or more. The 60 proteins overexpressed included the methane and carbohydrate metabolic enzymes, while the 68 proteins suppressed were mainly responsible for cellular signaling processes, indicating a role of copper ions in the expression of the genes associated with the metabolism of the organism downstream of methane oxidation. The study has also provided a complete
    关键词: Biochemistry & Molecular Biology
    日期: 2004-12-03
    關聯: Journal of Biological Chemistry. 2004 Dec;279(49):51554-51560.
    Link to: http://dx.doi.org/10.1074/jbc.M408013200
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1083-351X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000225355800110
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=19944397800
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