國家衛生研究院 NHRI:Item 3990099045/2366
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    题名: Molecular profiling of tyrosine kinases in normal and cancer cells
    作者: Kung, HJ;Chen, HC;Robinson, D
    贡献者: Division of Molecular and Genomic Medicine;Division of Biotechnology and Pharmaceutical Research
    摘要: As the post-genome era is approaching, with vast amount of sequence information available and new technology developed, scientists are presented with opportunities to explore in simple analysis the structure and expression pattern of not just a single gene, but of an entire family of genes, if not the entire genome. The concept of 'molecular profiling' or 'expression array' has thus emerged. The need to simultaneously 'see' all genes in the same family is obvious under the precept of the combinatorial process being an underlying principle of complex biological systems: no gene exists in isolation, for virtually every molecule participates in intermolecular interactions. The activation of receptor tyrosine kinases through home or hetero-dimerization is the prototypic example. In this review, a tyrosine kinase profile technique and its application to studying the expression of tyrosine kinases and the identification of novel kinases will be discussed. This serves as an introduction to the several interesting papers published in this special 'kinase' issue of the Journal of Biomedical Sciences, using this technique. A new simplified approach, kinase display, which is an extension of the profiling method and requires only restriction digestion and gel analysis will also be introduced.
    关键词: Medicine, Research & Experimental
    日期: 1998-03
    關聯: Journal of Biomedical Science. 1998 Mar;5(2):74-78.
    Link to: http://dx.doi.org/10.1007/BF02258359
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-7770&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000074139900002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031799251
    显示于类别:[龔行健] 期刊論文
    [陳華鍵(1997-2001)] 期刊論文

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