國家衛生研究院 NHRI:Item 3990099045/2368
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    题名: Tyrosine kinase expression profiles of chicken erythro-progenitor cells and oncogene-transformed erythroblasts
    作者: Robinson, D;Chen, HC;Li, DS;Yustein, JT;He, F;Lin, WC;Hayman, MJ;Kung, HJ
    贡献者: Division of Molecular and Genomic Medicine;Division of Biotechnology and Pharmaceutical Research
    摘要: Tyrosine kinases are implicated in the growth and differentiation of erythroid cells. Aberrant expression and structural alterations of certain tyrosine kinases, such as erbB and sea, are known to trigger erythroleukemia development. To facilitate our understanding of the signal transduction pathways involved in erythroid differentiation and leukemic transformation, we have applied a recently developed tyrosine kinase profile technique to identify the tyrosine kinases and some novel serine/threonine kinases expressed in normal chicken erythroid progenitor cells that respond to TGF alpha (TGF alpha-EB), and erythroblasts transformed by viruses encoding v-erbB (v-erbB-EB) and v-sea (v-sea-EB). Our results reveal that the non-receptor tyrosine kinases, Abl, Fyn, Lyn, Btk and Csk, are expressed in all three cell types. The expression level of Btk, a tyrosine kinase implicated in Bruton's syndrome, is exceptionally high in the erythroblastoid cell line 6C2, transformed by the v-erbB carrying avian erythroblastosis virus, AEV-ES4. We have also uncovered a new STE-20-related serine/threonine kinase, KFC, which is abundantly expressed in both the TGF alpha-stimulated erythroid progenitor cells and v-sea-transformed erythroblasts. Based on sequence homology of the kinase domain, KFC appears to be the first member of a new subfamily of STE-20-like kinases.
    关键词: Medicine, Research & Experimental
    日期: 1998-03
    關聯: Journal of Biomedical Science. 1998 Mar;5(2):93-100.
    Link to: http://dx.doi.org/10.1007/BF02258362
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-7770&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000074139900005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031775821
    显示于类别:[龔行健] 期刊論文
    [陳華鍵(1997-2001)] 期刊論文

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