國家衛生研究院 NHRI:Item 3990099045/2377
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2377


    Title: Level of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls (PCDD/Fs, PCBs) in human milk and the input to infant body burden
    Authors: Chao, HR;Wang, SL;Lee, CC;Yu, HY;Lu, YK;Papke, O
    Contributors: Division of Environmental Health and Occupational Medicine
    Abstract: This study determined PCDD/F and PCB levels in human milk, examined factors associated with levels of contamination, and assessed the infant body burden from breast-feeding. The congeners of PCDD/Fs, dioxin-like PCBs, and indicator PCBs were analyzed by HRGC/HRMS for 36 human milk samples from healthy women, aged 20-35 years, from December 2000 to November 2001 in central Taiwan. Mean levels of WHO-TEQs in human milk were 10.5 (95% CI = 8.8-12.2) and 14.5 (95% CI = 12.5-16.5) pg-TEQ/g lipid for those <29 and greater than or equal to29 years old, respectively. PCB 138 concentration significantly predicted total WHO-TEQs with r(2) = 0.84 (p < 0.001). Milk level of dioxin-TEQ was 9.63 pg-TEQ/g lipid (95% CI = 7.0-13.2) in those with a yearly income $29,000 compared to 6.3 pg-TEQ/g lipid (95% CI = 5.2-7.6) for those whose yearly income was $18,000 per year. Women who reported being Buddhist (64.3 ng/g lipid) had significantly higher indicator PCB concentrations than did those who reported being Taoist (35.3 ng/g lipid). The monthly dioxin intake of exclusively breastfed infants decreased with increasing duration of lactation. The cumulative dose of exclusively breastfed infants (76.5 ng TEQ, 95% CI = 69.7-83.3) was significantly greater compared to that of formula-fed infants (CI = 16.4-17.0) at one year and to that of infants at birth (3.90 ng TEQ, 95% CI = 3.6-4.2). Our findings suggest that breast-feeding should be strongly encouraged for infants in Taiwan. (C) 2004 Elsevier Ltd. All rights reserved.
    Keywords: Food Science & Technology;Toxicology
    Date: 2004-08
    Relation: Food and Chemical Toxicology. 2004 Aug;42(8):1299-1308.
    Link to: http://dx.doi.org/10.1016/j.fct.2004.03.008
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0278-6915&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000222549400013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=2942640015
    Appears in Collections:[Shu-Li Wang] Periodical Articles

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