國家衛生研究院 NHRI:Item 3990099045/2400
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    题名: Genetic polymorphisms of XRCC1 and risk of the esophageal cancer
    作者: Lee, JM;Lee, YC;Yang, SY;Yang, PW;Luh, SP;Lee, CJ;Chen, CJ;Wu, MT
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: A variety of environmental factors were identified to be associated with the risk of esophageal cancer. The variation in capacity of DNA repair might influence environmental chemical-associated carcinogenesis. We hypothesized that the polymorphic XRCCI genes might modify cancer susceptibility of the esophagus. To investigate the effect of XRCCI genetic polymorphisms an codons 194, 280 and 399, we evaluated data from 105 patients of esophageal squamous cell carcinoma and 264 healthy controls, matching with age (+/-3 years), gender and ethnicity, The distribution of the 3 genotypes were not significantly different among patients and controls, However, among alcohol drinkers, the XRCCI399 Arg/Arg genotype was move frequently found in patients with esophageal cancer. After adjustment with other environmental confounders, the OR for the genotype of XRCCI399 Arg/Arg was 2.78 (95% CI = 1.15-6.67) as compared with the XRCCI399 Arg/Gln and XRCCI399 Gln/Gln genotypes in the alcohol drinkers. Similar trends were observed among cigarette smokers and areca chewers. However, they did not reach a statistical significance. Our findings suggest that the polymorphic XRCCI genes might modify the risk of alcohol-associated esophageal cancers. (C) 2001 Wiley-Liss, Inc.
    关键词: Oncology
    日期: 2001-07-20
    關聯: International Journal of Cancer. 2001 Jul;95(4):240-246.
    Link to: http://www3.interscience.wiley.com/journal/82002361/abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0020-7136&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000169564700007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035919865
    显示于类别:[吳明蒼(2000-2001)] 期刊論文

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