國家衛生研究院 NHRI:Item 3990099045/2408
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    題名: Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers
    作者: Hsu, PC;Chen, IY;Pan, CH;Wu, KY;Pan, MH;Chen, JR;Chen, CJ;Chang-Chien, GP;Hsu, CH;Liu, CS;Wu, MT
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Objectives: The aim was to determine whether occupational exposure to polycyclic aromatic hydrocarbons (PAHs) in men has adverse effect on semen quality. Methods: Forty-eight coke-oven workers, including 16 topside-oven (TO) workers and 32 sideoven (SO) workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyrene (1-OHP) levels, and parameters of semen quality were determined. Results: TO workers had significantly higher ambient PAHs exposure (3,436.1 +/- 3,411.0 vs. 1,123.1 +/- 1,829.3 ng/m(3), P < 0.01), urinary 1-OHP levels (207.8 +/- 176.4 vs. 54.0 +/- 44.8 mu g/g, P < 0.001), frequency of oligospermia (18.8 vs. 0%, P < 0.05), and morphological abnormality in sperm (32.3 vs. 14.6%, P < 0.01) than SO workers. Among cigarette smokers, TO workers had significantly higher rates of DNA denaturation in spermatozoa (alpha T) and percentage of sperm with increased DNA denaturation (COMP alpha T) levels than SO workers (246.2 +/- 49.5 vs. 198.1 +/- 30.3 for alpha T; 34.8 +/- 14.4 vs. 19.3 +/- 13.9% for COMP alpha T, P < 0.05). There was a positive correlation between urinary 1-OHP and alpha T, COMP alpha T, and abnormal sperm morphology and a tenfold increase in urinary 1-OHP associated with a 2.35-fold increase in alpha T, as well as a 1.07-fold increase in percentage of sperm with abnormal morphology. Conclusions: A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP can be used as a biomarker predicting sperm dysfunction.
    關鍵詞: Public, Environmental & Occupational Health
    日期: 2006-05
    關聯: International Archives of Occupational and Environmental Health. 2006 May;79(5):349-356.
    Link to: http://dx.doi.org/10.1007/s00420-005-0066-3
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0340-0131&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000236355600002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33645168089
    顯示於類別:[吳焜裕(2001-2008)] 期刊論文

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