國家衛生研究院 NHRI:Item 3990099045/2412

NHRI > National Institute of Environmental Health Sciences > Kuen-Yuh Wu(2001-2008) > Periodical Articles > Item 3990099045/2412

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2412

Title:	Urinary biomarker of oxidative stress correlating with outcome in critically septic patients
Authors:	Cheng, WE;Shih, CM;Hang, LW;Wu, KY;Yang, HL;Hsu, WH;Hsia, TC
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Objective: To determine whether urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), an in vivo parameter of oxidative stress, is correlated with the outcome of critically septic patients. Design and setting: Clinical outcome study in an adult medical intensive care unit (ICU). Patients:85 consecutive septic patients (59 men, 26 women). Measurements and results: Patient characteristics and the clinical course were examined. Urinary 8-OHdG was analyzed using isotope-dilution liquid chromatography with tandem mass spectrometry (LC/MS/MS). ICU mortality was 25.9% (22/85) and hospital mortality 38.8% (33/85). Survivors' APACHE II scores on days 1 and 3 and the difference between them differed significantly from those of nonsurvivors (day 1, 21.0 +/- 7.1 vs. 25.9 +/- 8.0; day 3, 15.0 +/- 5.8 vs. 23.2 +/- 8.3; difference, 6.0 +/- 5.5 vs. 1.7 +/- 6.6). Urinary 8-OHdG was significantly lower in survivors than in nonsurvivors on day 1 (1.8 +/- 2.4 vs. 3.0 +/- 2.4). The area under receiver operating characteristic curve analysis for the association between day 1 urinary 8-OHdG and ICU mortality was 0.71. The comparison performed upon discharge from hospital revealed similar results. Conclusions: This is a preliminary study. Excretion of urinary 8-OHdG, as measured using isotope-dilution LC/MS/MS, and the APACHE II score were correlated with the outcome of critically septic patients in medical ICU.
Keywords:	Critical Care Medicine
Date:	2007-07
Relation:	Intensive Care Medicine. 2007 Jul;33(7):1187-1190.
Link to:	http://dx.doi.org/10.1007/s00134-007-0628-9
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0342-4642&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000248002000014
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34447136278
Appears in Collections:	[Kuen-Yuh Wu(2001-2008)] Periodical Articles

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