國家衛生研究院 NHRI:Item 3990099045/2417
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    题名: Rapid and sensitive on-line liquid chromatographic/tandem mass spectrometric determination of an ethylene oxide-DNA adduct, N7-(2-hydroxyethyl)guanine, in urine of nonsmokers
    作者: Huang, CCJ;Shih, WC;Wu, CF;Chen, MF;Chen, YL;Lin, YH;Wu, KY
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Ethylene oxide (EtO) is classified as a known human carcinogen. The formation of EtO-DNA adducts is considered as an important early event in the EtO carcinogenic process. An isotope-dilution on-line solid-phase extraction and liquid chromatography coupled with tandem mass spectrometry method was then developed to analyze one of the EtO-DNA adducts, N7-(2-hydroxyethyl)guanine (N7-HEG), in urine of 46 nonsmokers with excellent accuracy, sensitivity and specificity. The merits of this method include small sample volume (only 120 mu L urine required), automated sample cleanup, and short total run time (12 minutes per sample). This method demonstrates its high-throughput capacity for future molecular epidemiology studies on the potential health effects resulting from the low-dose EtO exposure.
    关键词: Chemistry, Analytical;Spectroscopy
    日期: 2008-03-15
    關聯: Rapid Communications in Mass Spectrometry. 2008 Mar 15;22(5):706-710.
    Link to: http://dx.doi.org/10.1002/rcm.3414
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0951-4198&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000254172700015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=40649086902
    显示于类别:[吳焜裕(2001-2008)] 期刊論文

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