國家衛生研究院 NHRI:Item 3990099045/2421

NHRI > National Institute of Environmental Health Sciences > Kuen-Yuh Wu(2001-2008) > Periodical Articles > Item 3990099045/2421

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2421

Title:	Two-sample scale tests for comparison of metabolic rates for styrene in previously exposed and unexposed groups
Authors:	Chen, CC;Wu, KY;Balakrishnan, N
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Statistical analysis procedure in two-sample treatment difference, as well as alternative hypothesis, may play a central role in statistical inference, especially in small sample size case. In this paper, simple non-parametric two-sample permutation tests for scale difference based on the Hodges-Lehmann estimator are reformulated, and are applied to a study examining whether previous styrene exposure increases (thus a one-sided alternative hypothesis rather than a two-sided one) the human liver's metabolic ability to convert styrene into styrene oxide, in which a three-compartment physiologically based pharmacokinetic (PBPK) model was used to compare the estimated metabolic constant K among the previously exposed and unexposed groups. Contrary to the previous conclusion, the proposed tests for scale difference identified from a mixed-effects model showed a significant result.
Keywords:	Mathematical & Computational Biology;Public, Environmental & Occupational Health;Medical Informatics;Medicine, Research & Experimental;Statistics & Probability
Date:	2004-02-28
Relation:	Statistics in Medicine. 2004 Feb;23(4):591-599.
Link to:	http://dx.doi.org/10.1002/sim.1617
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0277-6715&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000188737900005
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1142263237
Appears in Collections:	[Kuen-Yuh Wu(2001-2008)] Periodical Articles

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