國家衛生研究院 NHRI:Item 3990099045/2427

NHRI > National Institute of Environmental Health Sciences > Kuen-Yuh Wu(2001-2008) > Periodical Articles > Item 3990099045/2427

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2427

Title:	Selective inhibition of collagen-induced platelet aggregation by a cyclic peptide from Drymaria diandra
Authors:	Hsieh, PW;Chang, FR;Wu, CC;Wu, KY;Li, CM;Wang, WY;Gu, LC;Wu, YC
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Four cyclic peptides, diandrine A-D (1-4), were isolated from the MeOH extract of Formosan Drymaria diandra. Their structures were elucidated by chemical and spectroscopic analyses as cyclo(-Gly(1)-Pro(2)-Trp(3)-Pro(4)-Tyr(5)-Phe(6)-), cyclo(-Gly(1)-Pro(2)-Leu(3)-Pro(4)-Leu(5)-Trp(6)-Ser(7)-Ser(8)-) cyclo(Gly(1)-Gly(2)-Pro(3)-Tyt(4)-Trp(5)-Pro(6)-), and cyclo(Gly(1)-Gly(2)-Pro(3)-Tyr(4)-Trp(5)-Pro(6)-), respectively. Compounds 3 and 4 were stable conformational isomers. Cyclopeptide 1 showed a selective inhibitory effect on collagen-induced platelet aggregation with an IC50 value of 44.2 lot.
Keywords:	Chemistry, Multidisciplinary
Date:	2004
Relation:	Helvetica Chimica Acta. 2004;87(1):57-66.
Link to:	http://dx.doi.org/10.1002/hlca.200490017
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0018-019X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000189190900005
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1342323919
Appears in Collections:	[Kuen-Yuh Wu(2001-2008)] Periodical Articles

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