國家衛生研究院 NHRI:Item 3990099045/2447
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    題名: Lead exposure is associated with decreased serum paraoxonase 1 (PON1) activity and genotypes
    作者: Li, WF;Pan, MH;Chung, MC;Ho, CK;Chuang, HY
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Lead exposure causes cardiac and vascular damage in experimental animals. However, there is considerable debate regarding the causal relationship between lead exposure and cardiovascular dysfunction in humans. Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, is capable of hydrolyzing oxidized lipids and thus protects against atherosclerosis. Previous studies have shown that lead and several other metal ions are able to inhibit PON1 activity in vitro. To investigate whether lead exposure has influence on serum PON1 activity, we conducted a cross-sectional study of workers from a lead battery manufactory and lead recycling plant. Blood samples were analyzed for whole-blood lead levels, serum PON1 activity, and three common PON1 polymorphisms (Q192R, L55M, -108C/T). The mean blood lead level (+/- SD) of this cohort was 27.1 +/- 15 mu g/dL. Multiple linear regression analysis showed that blood lead levels were significantly associated with decreased serum PON1 activity (p < 0.001) in lead workers. This negative correlation was more evident for workers who carry the R192 allele, which has been suggested to be a risk factor for coronary heart disease. Taken together, our results suggest that the decrease in serum PON1 activity due to lead exposure may render individuals more susceptible to atherosclerosis, particularly subjects who are homozygous for the R192 allele.
    關鍵詞: Environmental Sciences;Public, Environmental & Occupational Health
    日期: 2006-08
    關聯: Environmental Health Perspectives. 2006 Aug;114(8):1233-1236.
    Link to: http://dx.doi.org/10.1289/ehp.9163
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0091-6765&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000239468000047
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33746877938
    顯示於類別:[李婉芬(2001-2009)] 期刊論文

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