國家衛生研究院 NHRI:Item 3990099045/2502

NHRI > National Institute of Environmental Health Sciences > Ying-Chin Ko(2003-2009) > Periodical Articles > Item 3990099045/2502

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2502

Title:	Cancer aggregation and complex segregation analysis of families with female non-smoking lung cancer probands in Taiwan
Authors:	Wu, PF;Lee, CH;Wang, MJ;Goggins, WB;Chiang, TA;Huang, MS;Ko, YC
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Previous studies have found that having a first-degree blood relative with lung cancer was a possible predictor of lung cancer risk, but some studies have indicated that the association is non-significant or only significant for a subset of the studied population. To determine the familial aggregation and whether there is any evidence for a gene controlling the susceptibility to developing lung cancer in female non-smokers, multiple logistic regression methods for estimating covariate effects and maximum likelihood segregation analyses were performed using data from 216 female non-smoking lung cancer probands (2328 individuals) in a population-based case-control study. Having a family history of lung cancer was found to be a significant predictor of lung cancer for nonsmoking females (Adjusted Odds Ratio (OR) = 5.7, 95% Confidence Interval (CI) = 1.9-16.9). Having a female relative with lung cancer (adjusted OR = 14.4, 95% CI = 2.7-75.5) was more strongly associated with the lung cancer risk than was having a male relative with lung cancer. This association was stronger for probands aged less than 60 years at onset (adjusted OR = 11.2, 95% CI = 2.2-56.9). All of the Mendelian models fitted the data significantly better than the sporadic (no major type) model or the environmental model (P < 0.001). The Mendelian codominant models provided the best fit of the data for the early onset probands and showed a stronger effect for a major susceptibility locus for non-smoking lung cancer probands. The results of this study provide evidence that a rare autosomal codominant gene may influence the risk lung cancer in non-smoker and is responsible for the familial aggregation observed in non-smoking lung cancer patients. (C) 2003 Elsevier Ltd. All rights reserved.
Keywords:	Oncology
Date:	2004-01
Relation:	European Journal of Cancer. 2004 Jan;40(2):260-266.
Link to:	http://dx.doi.org/10.1016/j.ejca.2003.08.021
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0959-8049&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000188757700021
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0346023952
Appears in Collections:	[Ying-Chin Ko(2003-2009)] Periodical Articles

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