國家衛生研究院 NHRI:Item 3990099045/2505
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    題名: Personal history and family history as a predictor of gastric cardiac adenocarcinoma risk: A case-control study in Taiwan
    作者: Chen, MJ;Wu, DC;Ko, YC;Chiou, YY
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: OBJECTIVES: To clarify the risk of gastric cardiac adenocarcinoma for patients with a personal and/or family history of gastrointestinal diseases. METHODS: The present study was a hospital-based case-control study conducted from 1992 to 1997 in Kaohsiung, Taiwan, consisting of 176 cases and 579 controls matched by age, sex, and time of hospitalization. With informed oral consent, each subject completed a structured questionnaire during hospitalization regarding sociodemographic status, lifestyle, and health history. RESULTS: The response rate was 98%. Adjusting for age, sex, years of schooling, socioeconomic status, body mass index (BMI), and smoking. Multivariate logistic regression models indicated a reduced effect for patients with a personal history of duodenal ulcer (DU) (odds ratio (OR) = 0.8, 95% confidence interval (CI) 0.5-0.9). No association was observed between the risk of gastric cardiac cancer and other forms of gastric disease. Furthermore, we also demonstrated that individuals with a family history of gastric cancer had a higher risk than those who lacked a family history (OR = 2.5, 95% CI 1.3-4.8). CONCLUSIONS: Our findings provide further evidence that individuals with DU history are less likely to have gastric cardiac cancer, and we infer that Helicobacter pylori (H. pylori) infection (85-95% DU patients infected with H. pylori) alone may not be sufficient to cause gastric cardiac adenocarcinoma. In addition, this study also suggests that a positive family history of gastric cancer may predict an increased risk for the disease.
    關鍵詞: Gastroenterology & Hepatology
    日期: 2004-07
    關聯: American Journal of Gastroenterology. 2004 Jul;99(7):1250-1257.
    Link to: http://dx.doi.org/10.1111/j.1572-0241.2004.30872.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9270&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000222641800012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=3843087380
    顯示於類別:[葛應欽(2003-2009)] 期刊論文

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