國家衛生研究院 NHRI:Item 3990099045/2570
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 855490      線上人數 : 1150
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/2570


    題名: Liquid chromatography/tandem mass spectrometric method for the simultaneous determination of tobacco-specific nitrosamine NNK and its five metabolites
    作者: Lee, HL;Wang, CY;Lin, S;Hsieh, DPH
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: A sensitive and robust high-performance liquid chromatography-electrospray ionization tandem mass spectrometry method to analyze 4(methylnitrosamino)-1-(3-pyridyl)-l-butanone (NNK) and its five metabolites in one passage was developed and validated. The method achieved excellent reproducibility and accuracy. Linearity was observed for all six compounds (R-2 = 0.999) with detection limits (S/N >= 3) ranging from 0.2 to 2.4pg on column and 0.01-0.12ngm(-l) in samples injected. Average intra-day and inter-day variations (% R.S.D.) were 1.2 and 3.5%, respectively. A sample preparation method involving C8 and C18 solid phase extraction provided satisfactory recovery of the analytes in mouse urine. Each NNK metabolite was identified by its chromatographic retention time and specific fragmentation pattern. Since the carcinogenicity of NNK is related to its metabolism, the method described in this report should facilitate toxicological investigations into the carcinogenesis due to NNK exposure in the environment. (c) 2007 Elsevier B.V. All rights reserved.
    關鍵詞: Chemistry, Analytical
    日期: 2007-08-15
    關聯: Talanta. 2007 Aug;73(1):76-80.
    Link to: http://dx.doi.org/10.1016/j.talanta.2007.03.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0039-9140&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000249174700010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34547136468
    顯示於類別:[謝顯堂(2004-2007)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    000249174700010.pdf149KbAdobe PDF1188檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋