國家衛生研究院 NHRI:Item 3990099045/2597
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    题名: The association between urinary albumin excretion and ankle-brachial index in elderly Taiwanese patients with type 2 diabetes mellitus
    作者: Tseng, CH;Chong, CK;Tseng, CP;Tai, TY
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Objective: this study examined the association between urinary albumin/creatinine ratio (ACR) and ankle-brachial index (ABI), or peripheral arterial disease (PAD), in elderly patients with type 2 diabetes mellitus (T2DM). Methods: a total of 290 (108 men, 182 women) T2DM, aged 65 (71.6 4.9) years were recruited. PAD was diagnosed by ABI0.9, and ACR was divided into normoalbuminuria (30.0 g/mg), microalbuminuria (30.0 299.9 g/mg), and macroalbuminuria ( 300.0 g/mg). Results patients with PAD (n = 45) had higher ln(ACR) than patients without: 4.48 +/- 1.48 versus 3.73 +/- 1.39 (P< 0.01). For normoalbuminuria (n = 112), microalbuminuria (n = 152), and macroalbuminuria (n = 26), respective PAD prevalence was 8.0, 17.1 and 38.5% (P< 0.001). The proportion of normoalbuminuria, microalbuminuria and macroalbuminuria in patients with PAD was 20.0, 57.8 and 22.2%, respectively; and 42.0, 51.4 and 6.5%, respectively, in patients without (P< 0.001). Ln(ACR) was inversely correlated with ABI in all patients (gamma = - 0.198, P< 0.01) and in separate sexes (gamma = - 0.211 for men and gamma = - 0.181 for women). The multivariate-adjusted odds ratios for PAD for every 1 unit increment of ln(ACR) was 1.66 (1.17-2.34); and for microalbuminuria versus normoalbuminuria and macroalbuminuria versus normoalbuminuria were 2.54 (1.05-6.17) and 5.86 (1.76-19.52), respectively. Conclusions: urinary ACR is not only associated with PAD, it is also significantly correlated with ABI in an inverse pattern in elderly Taiwanese with T2DM.
    关键词: Geriatrics & Gerontology
    日期: 2008-01
    關聯: Age and Ageing. 2008 Jan;37(1):77-82.
    Link to: http://dx.doi.org/10.1093/ageing/afm148
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-0729&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000252498100015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38549176256
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