國家衛生研究院 NHRI:Item 3990099045/2669
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    題名: Anti-tumor immunoglobulin M increases lung metastasis in an experimental model of malignant melanoma
    作者: Tsai, NM;Chen, BM;Wei, SL;Wu, CW;Roffler, SR
    貢獻者: National Institute of Cancer Research
    摘要: Cancer metastasis involves distinct steps that depend on complicated tumor-host interactions. The hematogenous dissemination of tumor cells may be facilitated by factors that promote the arrest and adherence of cancer cells in capillaries. We examined whether anti-tumor monoclonal inummoglobulin M (IgM) antibodies promoted the hematogenous dissemination of B 16 melanoma cells in syngeneic mice. IgM monoclonal antibodies were generated that selectively bind to B 16 melanoma cells as compared to syngeneic fibroblasts, lymphocytes or Lewis lung carcinoma cells. Incubation of B16-BL6 or B 16-F0 melanoma cells with these IgM anti-tumor antibodies significantly increased the number of lung colonies as compared with control antibodies. Moreover, intraperitoneal injection of specific antibody also significantly increased lung colonization. All anti-tumor antibodies promoted the aggregation of B16 melanoma cells. A chemically generated immunoglobulin G (IgG)-like fragment of an anti-tumor IgM antibody displayed greatly reduced tumor aggregation and, in contrast to intact IgM, did not significantly increase lung colonization of B16 melanoma cells. Neither intact IgM nor the IgG-like fragment enhanced the in vitro invasiveness of B16 melanoma cells across Matrigel-coated membranes. Our results, therefore, suggest that besides their beneficial anti-tumor effects, anti-tumor IgM antibodies may also promote the hematogenous dissemination of cancer cells.
    關鍵詞: Oncology
    日期: 2003
    關聯: Clinical and Experimental Metastasis. 2003;20(2):103-109.
    Link to: http://dx.doi.org/10.1023/A:1022616223359
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0262-0898&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000181395100002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037247640
    顯示於類別:[吳成文(1996-2008)] 期刊論文

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