國家衛生研究院 NHRI:Item 3990099045/2674
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    题名: Functional analysis of EBV in nasopharyngeal carcinoma cells
    作者: Wu, HC;Lin, YJ;Lee, JJ;Liu, YJ;Liang, ST;Peng, Y;Chiu, YW;Wu, CW;Lin, CT
    贡献者: National Institute of Cancer Research
    摘要: A membrane invasion culture system was used to study the ability of EBV to enhance invasion and migration of nasopharyngeal carcinoma (NPC) cells. Semi-reverse transcriptase-PCR analysis of matrix proteinases and angiogenic factors from EBV-infected, or EBV-positive (EBV+), cells demonstrated different degrees of elevated gene expression. In our animal model, EBV+ tumors grew faster and larger than EBV-free, or EBV-negative (EBV-), tumors and also had clonal EBV terminal repeat sequences. Double-localization of EBV and certain host proteins in EBV+ tumors and biopsy specimens demonstrated that EBV up-regulates host genes only in cells that express those genes but not in cells that do not express them. Double-localization of EBV and host genes in NPC biopsy specimens all showed EBV- tumor cells expressing those host genes. Our data strongly suggest that EBV infection enhances progression of NPC tumor growth. They do not rule out a role for EBV infection in the induction and early promotion of NPC development. Unidentified factors may also enhance NPC tumor growth independent of the effects of EBV.
    关键词: Medicine, Research & Experimental;Pathology
    日期: 2003-06
    關聯: Laboratory Investigation. 2003 Jun;83(6):797-812.
    Link to: http://www.nature.com/labinvest/journal/v83/n6/abs/3780667a.html
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0023-6837&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000183718700004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0038002724
    显示于类别:[吳成文(1996-2008)] 期刊論文

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