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http://ir.nhri.org.tw/handle/3990099045/2675
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| Title: | Antitumor and antimetastatic activity of IL-23 |
| Authors: | Lo, CH;Lee, SC;Wu, PY;Pan, WY;Su, J;Cheng, CW;Roffler, SR;Chiang, BL;Lee, CN;Wu, CW;Tao, MH |
| Contributors: | National Institute of Cancer Research |
| Abstract: | The structure and T cell stimulatory effects of the recently discovered cytokine IL-23 are similar to, but distinct from, those of IL-12. Although the antitumor activities of IL-12 are well characterized, the effect of IL-23 on tumor growth is not known. In this study, murine CT26 colon adenocarcinoma and B16F1 melanoma cells were engineered using retroviral vectors to release single-chain IL-23 (scIL-23) to evaluate its antitumor activity. In BALB/c mice, scIL-23-transduced CT26 cells grew progressively until day 26 to an average size of 521 +/- 333 mm(3), then the tumors started to regress in most animals, resulting in a final 70% rate of complete tumor rejection. scIL-23 transduction also significantly suppressed lung metastases of CT26 and B16F1 tumor cells. In addition, mice that rejected scIL-23-transduced tumors developed a memory response against subsequent wild-type tumor challenge. Compared with scIL-12-expressing CT26 cells, scIL-23-transduced tumors lacked the early response, but achieved comparable antitumor and antimetastatic activity. These results demonstrated that IL-23, like IL-12, provided effective protection against malignant diseases, but it probably acted by different antitumor mechanisms. As a first step in identifying these antitumor mechanisms, tumor challenge studies were performed in immunocompromised hosts and in animals selectively depleted of various lymphocyte populations. The results showed that CD8(+) T cells, but not CD4(+) T cells or NK cells, were crucial for the antitumor activity of IL-23. |
| Keywords: | Immunology |
| Date: | 2003-07-15 |
| Relation: | Journal of Immunology. 2003 Jul;171(2):600-607. |
| Link to: | http://www.jimmunol.org/cgi/content/abstract/171/2/600 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-1767&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000184093800015 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037769934 |
| Appears in Collections: | [吳成文(1996-2008)] 期刊論文
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| 000184093800015.pdf | | 533Kb | Adobe PDF | 533 | View/Open |
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