國家衛生研究院 NHRI:Item 3990099045/2703
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2703


    Title: Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26
    Authors: Chang, WSW;Chang, NT;Lin, SC;Wu, CW;Wu, FYH
    Contributors: National Institute of Cancer Research
    Abstract: Approximately one quarter of the identified human serpin genes are cancer-related and clustered mainly at two distinct loci: 6p25 and 18q21. We have studied a novel serpin gene cluster at 3q26 containing at least two recently identified members: the pancreas-specific protease inhibitor, pancpin (PI14), and the brain-associated protease inhibitor, neuroserpin (PI12). In this, unlike a previous study, both PI14 and PI12 at 3q26 were found to consist of 9 exons and 8 introns and to share a perfectly conserved gene organization whose pattern is very different from that of the ov-serpin family. This distinct pattern appears identical in the genomic structures of human plasminogen activator inhibitor-1 (PA11) at 7q21 and protease nexin 1 (PI7) at 2q33-35, confirming that these four genes in three different chromosomes form a discrete subset within the serpin superfamily. As in the other three members whose gene expression is altered during tumorigenesis, PI12 expression was found to be down-regulated in tumor brain tissues and in two brain cancer cell lines: U-87 MG and H4, By screening genomic libraries, we isolated two overlapping clones showing that the marker SGC32223 (centromere) is located within intron F of PI12 and the marker WI-10077 (telomere) is located downstream of the 3'-flanking region of PI14. This finding indicates that the distance between human PI14 and PI12 is similar to 100 kb, and hence we speculate that other tissue-specific cancer-related serpin genes are likely to reside within this 3q26.1 cluster region. (C) 2000 Wiley-Liss, Inc.
    Keywords: Oncology;Genetics & Heredity
    Date: 2000-11
    Relation: Genes Chromosomes and Cancer. 2000 Nov;29(3):240-255.
    Link to: http://www3.interscience.wiley.com/journal/72513882/abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1045-2257&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000089805400006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033795221
    Appears in Collections:[Wun-Shaing Wayne Chang] Periodical Articles
    [Cheng-Wen Wu(1996-2008)] Periodical Articles

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