國家衛生研究院 NHRI:Item 3990099045/2706
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    题名: Association between vitamin D receptor polymorphisms and prostate cancer risk in a Taiwanese population
    作者: Huang, SP;Chou, YH;Chang, WSW;Wu, MT;Chen, YY;Yu, CC;Wu, TT;Lee, YH;Huang, JK;Wu, WJ;Huang, CH
    贡献者: National Institute of Cancer Research
    摘要: Recent molecular epidemiological studies have shown that the inherited polymorphisms of VDR gene may be linked to prostate cancer risk and its aggressive phenotypes. However, the findings remain inconclusive. In this study, we investigated the association of the BsmI, ApaI and TaqI polymorphisms of VDR gene with prostate cancer risk in a Taiwanese population. In total, 160 prostate cancer patients and 205 age-matched male controls were studied between December 2000 and February 2003. No significant associations were found between the ApaI and TaqI polymorphisms and the risk of prostate cancer. However, the control group was found to have a significantly higher frequency of the BsmI `BB' and `Bb' genotypes (15.6%) than prostate cancer patients (8.1%). After adjustment for age, patients with Bsm I `BB' or `Bb' genotypes were associated with a twofold decreased risk (OR = 0.50; 95%CI = 0.25-0.98; P = 0.045) for developing prostate cancer than those with `bb' genotypes. This effect was particularly significant among men below the median age of 72 years (P = 0.017). Moreover, stronger associations were found in the advanced stages (T3/T4/N1/M1) and poorly differentiated disease (Gleason score greater than or equal to 7) (`BB' and `Bb' vs `bb': OR = 0.25; 95%CI = 0.07-0.83; P = 0.024 and OR = 0.25; 95%CI = 0.07-0.85; P = 0.026, respectively). Our findings suggest that the VDR BsmI polymorphism may play a significant role in the development of prostate cancer. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
    关键词: Oncology
    日期: 2004-04-15
    關聯: Cancer Letters. 2004 Apr;207(1):69-77.
    Link to: http://dx.doi.org/10.1016/j.canlet.2003.12.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3835&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000220931600008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=12144289486
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