國家衛生研究院 NHRI:Item 3990099045/2739
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    題名: Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy
    作者: Chang, WSW;Chou, RH;Wu, CW;Chang, JY
    貢獻者: National Institute of Cancer Research
    摘要: The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. in this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.
    關鍵詞: Medicine, Legal;Pharmacology & Pharmacy
    日期: 2007-10
    關聯: Expert Opinion on Therapeutic Patents. 2007 Oct;17(10):1227-1240.
    Link to: http://dx.doi.org/10.1517/13543776.17.10.1227
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1354-3776&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000250732200003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=36148991024
    顯示於類別:[張俊彥] 期刊論文
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