國家衛生研究院 NHRI:Item 3990099045/2802
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    题名: Four new 6-Nor-5(6 →7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides
    作者: Chang, CI;Chang, JY;Kuo, CC;Pan, WY;Kuo, YH
    贡献者: National Institute of Cancer Research
    摘要: Four new 6-nor-5(6-7)abeo-abietane type diterpenes designated as taiwaniaquinone G, taiwaniaquinone H, taiwamaquinol E and taiwamaquinol F and eight known diterpenes, taiwamaquinones A (5), D (6), E, F (8), and taiwaniaquinols A (9), B, C (11), D (12) were isolated from the bark of Taiwania cryptomerioides. Their Structures were elucidated on the basis of spectroscopic studies. These twelve diterpenes were evaluated for in vitro anti-tumoral cytotoxic activity. The result demonstrated that compounds 5, 6, 8, 9, 11, and 12 bearing an aldehyde group possessed potent cytotoxic activity against KB epidermoid carcinoma cancer cell lines with IC50 values of 6.9, 7.2, 4.4, 8.3, 8.1, and 3.5 muM, respectively.
    关键词: Plant Sciences;Chemistry, Medicinal;Pharmacology & Pharmacy
    日期: 2005-01
    關聯: Planta Medica. 2005 Jan;71(1):72-76.
    Link to: http://dx.doi.org/10.1055/s-2005-837754
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000227072500013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=13544276907
    显示于类别:[Ching-Chuan Kuo] Periodical Articles
    [Jang-Yang Chang] Periodical Articles

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