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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/2825
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| Title: | An open, multi-centre, phase II clinical trial to evaluate the efficacy and safety of paclitaxel, UFT, and leucovorin in patients with advanced gastric cancer |
| Authors: | Chao, Y;Li, CP;Chao, TY;Su, WC;Hsieh, RK;Wu, MF;Yeh, KH;Kao, WY;Chen, LT;Cheng, AL |
| Contributors: | National Institute of Cancer Research |
| Abstract: | The aim of the study was to evaluate the response rate and safety of weekly paclitaxel (Taxol (R)) combination chemotherapy with UFT (tegafur, an oral 5-fluorouracil prodrug, and uracil at a 1 : 4 molar ratio) and leucovorin (LV) in patients with advanced gastric cancer. Patients with histologically confirmed, locally advanced or recurrent/metastatic gastric cancer were studied. Paclitaxel 1-h infusion at a dose of 100 mgm(-2) on days 1 and 8 and oral UFT 300 mgm(-2) day(-1) plus LV 90 mg day(-1) were given starting from day 1 for 14 days, followed by a 7-day period without treatment. Treatment was repeated every 21 days. From February 2003 to October 2004, 55 patients were enrolled. The median age was 62 years (range: 32 - 82). Among the 48 patients evaluated for tumour response, two achieved a complete response and 22 a partial response, with an overall response rate of 50% (95% confidence interval: 35 - 65%). All 55 patients were evaluated for survival and toxicities. Median time to progression and overall survival were 4.4 and 9.8 months, respectively. Major grade 3 - 4 toxicities were neutropenia in 25 patients (45%) and diarrhoea in eight patients (15%). Although treatment was discontinued owing to treatment-related toxicities in nine patients (16%), there was no treatment-related mortality. Weekly paclitaxel plus oral UFT/LV is effective, convenient, and well tolerated in treating patients with advanced gastric cancer. |
| Keywords: | Oncology |
| Date: | 2006-07-17 |
| Relation: | British Journal of Cancer. 2006 Jul;95(2):159-163. |
| Link to: | http://dx.doi.org/10.1038/sj.bjc.6603225 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0007-0920&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000239118200005 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33745960387 |
| Appears in Collections: | [陳立宗] 期刊論文
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| 000239118200005.pdf | | 108Kb | Adobe PDF | 675 | View/Open |
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