國家衛生研究院 NHRI:Item 3990099045/2881
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    題名: Overexpression of cyclin A but not Skp 2 correlates with the tumor relapse of human hepatocellular carcinoma
    作者: Chao, Y;Shih, YL;Chiu, JH;Chau, GY;Lui, WY;Yang, WK;Lee, SD;Huang, TS
    貢獻者: National Institute of Cancer Research
    摘要: Cyclin A is an S- and G(2)-M-phase regulatory protein, and its abnormal expression has been implicated in cellular transformation, This work was undertaken to investigate the frequency of cyclin A overexpression and the correlated clinical outcome in human hepatocellular carcinoma (HCC), Herein, 12 of 31 (39%) patients exhibited cyclin A overexpression in their tumorous tissues, resulting from gene amplification in 6 of 12 patients, (post)transcription in 4 of 12 patients, and (post)translation in 2 of 12 patients, Patients who overexpressed cyclin A had significantly more tumor cells in the S and G(2)-M phases compared with those expressing a normal cyclin A level (P = 0.007 and 0.039, respectively), Increased levels of Skp 2, a cyclin A-interacting protein, were also found in 17 of 31 (55%) of HCC patients who showed a trend to have more S-phase tumor cells (P = 0.07), By an unpaired Student's t test and a Fisher's exact or chi(2) analysis, overexpression of cyclin A had a strong correlation with elevated Skp 2 expression and increased alpha-fetoprotein levels (P = 0.001 and 0.009, respectively), but it was not associated with patients' age, tumor size, cirrhosis, or the positive detection of hepatitis B virus surface antigen, In the disease-free survival analysis, patients whose tumors overexpressed cyclin A had a median disease-free survival of 6 months, whereas patients who lacked cyclin A overexpression exhibited a longer median period of 29 months (P = 0.046), The overall survival analysis revealed the same trend, i.e., cyclin A-overexpressing patients had shorter overall survival periods (median, 12 versus 50 months; P = 0.09), By multivariate analysis, the correlation of cyclin A overexpression with shorter disease-free periods remained significant after adjustment for Skp 2 overexpression and cu-fetoprotein induction (P = 0.019), These data suggest that overexpression of cyclin A can be an independent prognostic factor for the tumor relapse of human HCC.
    關鍵詞: Oncology
    日期: 1998-03-01
    關聯: Cancer Research. 1998 Mar;58(5):985-990.
    Link to: http://cancerres.aacrjournals.org/cgi/content/abstract/58/5/985
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000072252800023
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032030883
    顯示於類別:[黃智興] 期刊論文
    [楊文光(1996-1999)] 期刊論文

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