國家衛生研究院 NHRI:Item 3990099045/2906
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    题名: Restoration of cytotoxic T lymphocyte function in malignant pleural effusion: Interleukin-15 vs. interleukin-2
    作者: Chen, YM;Ting, CC;Peng, JW;Yang, WK;Yang, KY;Tsai, CM;Perng, RP
    贡献者: National Institute of Cancer Research
    摘要: The present study attempts to define the role of interleukin-15 (IL-15), as compared with IL-2, in generating cytotoxic T lymphocytes (CTL) from the malignant effusions of cancer patients. Effusion-associated lymphocytes (EAL) from malignant effusion were incubated with IL-15 or IL-2 with or without alpha CD3. Proliferation and cytotoxicity assays mere performed. IL-15 was found to have at least an equivalent, if not higher, activity to IL-2 in terms of lymphocyte proliferation and generation of CTL from EAL, The proliferative response of EAL, cocultured with IL-15, with or without alpha CD3, was partly inhibited by pretreatment with an anti-IL-2 receptor beta chain monoclonal antibody (mAb), The proliferative response of EAL, cocultured with alpha CD3, IL-2, or both, was partly inhibited by pretreatment with an anti-IL-2 receptor alpha chain mAb, Overnight [Cr-51] release assays against K562, Daudi, and the patients' autologous tumor cells were done to evaluate EAL's cytolytic activity. MHC class I Ab blocked the stimulated cytolytic activity of EAL against autologous tumors. An mAb depletion assay showed that the phenotype of the restored EAL was CD16(-)CD4(-)CD8(+); thus, the restored activity of EAL was CTL activity. The results suggest that both IL-15 and IL-2 can restore CTL activity from EAL in the presence of T cell receptor (TCR)-CD3 engagement, but the effect of IL-15 was superior.
    关键词: Biochemistry & Molecular Biology;Cell Biology;Immunology
    日期: 2000-01
    關聯: Journal of Interferon and Cytokine Research. 2000 Jan;20(1):31-39.
    Link to: http://dx.doi.org/10.1089/107999000312711
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1079-9907&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000085012900005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033969272
    显示于类别:[楊文光(1996-1999)] 期刊論文
    [彭汪嘉康(1996-2007)] 期刊論文

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