國家衛生研究院 NHRI:Item 3990099045/2989
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    题名: Phase II randomized study of weekly docetaxel alone or plus UFUR treatment in non-small cell lung cancer patients who failed previous chemotherapy
    作者: Chou, KT;Chen, YM;Shih, JF;Perng, RP;Tsai, CM;Whang-Peng, J
    贡献者: National Institute of Cancer Research
    摘要: Purpose: This study aimed to assess the feasibility and efficacy of adding UFUR (UFT, tegafur/uracil) into weekly docetaxel treatment for non-small cell lung cancer (NSCLC) patients who failed previous platinum-based chemotherapy. Methods: Patients were randomized into two arms: docetaxel 40mg/m(2) intravenous infusion (IV) on days 1 and 8 of every 3 weeks (arm D), and docetaxel 35 mg/m(2) IV on days 1 and 8 plus daily oral. UFUR 150 mg/m(2) of every 3 weeks (arm DU), with arm D as a control arm. Treatment was given to a maximum of 6 cycles and carried out in the outpatient clinic. Results: From January 2005 to March 2006, 48, patients were enrolled and randomized into the study, with 24 patients in each arm. The mean number of cycles of treatment was 4 in the D arm and 3.5 in the DU arm. Objective response rates were 29.2% in the D arm and 8.3% in the DU arm (p=0.067). Toxicities were few and mild in degree in both arms. Median time to disease progression was 4.5 months in the D arm and 2.1 months in the DU arm (p = 0.4682). Median survival time was 10.9 months in the D arm and 15.2 months in the DU arm (p = 0.8442). Conclusions: The addition of UFUR to weekly docetaxel treatment did not improve response rate and time to disease progression in NSCLC patients who failed previous platinum-based chemotherapy.
    关键词: Oncology;Respiratory System
    日期: 2008-01
    關聯: Lung Cancer. 2008 Jan;59(1):64-68.
    Link to: http://dx.doi.org/10.1016/j.lungcan.2007.07.016
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0169-5002&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000252690200008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=37549016343
    显示于类别:[彭汪嘉康(1996-2007)] 期刊論文

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