國家衛生研究院 NHRI:Item 3990099045/3029
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    題名: Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis
    作者: Huang, TS;Shu, CH;Yang, WK;WhangPeng, J
    貢獻者: National Institute of Cancer Research
    摘要: CDC 25 is a dual phosphatase responsible for dephosphorylation and, thus, activation of CDC 2 kinase in G(2). Abnormal activation of cyclin B-associated CDC 2 kinase has been in;plicated in apoptosis induced by cancer chemotherapeutic agents such as paclitaxel (Taxol) and etoposide (VP-16), In this study, we found that the CDC 2 kinase could be transiently activated when nasopharyngeal carcinoma NPC-TW01 cells were treated for 3 h with a new anticancer agent, GL331, GL331 treatment also induced a concomitant increase in CDC 25A phosphatase activity and a reduced level of Tyr-15-phosphorylated CDC 2 in NPC-TW01 cells, Furthermore, subsequent apoptotic DNA fragmentation induced by GL331 could be interrupted by treatment of the cells with the cyclin B1-specific antisense oligonucleotides, suggesting that abnormal activation of cyclin B1-associated CDC 2 kinase and CDC 25A phosphatase was involved in GL331-induced apoptosis, Raf-1 has been shown to associate with CDC 25A and, thus, to stimulate its phosphatase activity, Our results revealed that GL331 could facilitate the association of CDC 25A with Raf-1, resulting in the cascade of CD0C 25A phosphatase activation and CDC 2 kinase activation, as well as related signaling pathways, and ultimately causing apoptosis in cancer cells.
    關鍵詞: Oncology
    日期: 1997-07-15
    關聯: Cancer Research. 1997 Jul;57(14):2974-2978.
    Link to: http://cancerres.aacrjournals.org/cgi/content/abstract/57/14/2974
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:A1997XL16200032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030834333
    顯示於類別:[彭汪嘉康(1996-2007)] 期刊論文
    [楊文光(1996-1999)] 期刊論文
    [黃智興] 期刊論文

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