國家衛生研究院 NHRI:Item 3990099045/3034
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3034


    Title: Cytotoxicity of extractives from Taiwania cryptomerioides heart-wood
    Authors: Chang, ST;Wang, DSY;Wu, CL;Shiah, SG;Kuo, YH;Chang, CJ
    Contributors: National Institute of Cancer Research
    Abstract: The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated. Three human tumor cells including A-549 lung carcinoma, MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells. Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the turner cell death induced by taiwanin A was due to apoptosis.
    Keywords: Biochemistry & Molecular Biology;Plant Sciences
    Date: 2000-10
    Relation: Phytochemistry. 2000 Oct;55(3):227-232.
    Link to: http://dx.doi.org/10.1016/S0031-9422(00)00275-2
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-9422&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000165613100007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034739412
    Appears in Collections:[Shine-Gwo Shiah] Periodical Articles

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