國家衛生研究院 NHRI:Item 3990099045/3055
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    题名: Biodistribution, pharmacokinetics and microSPECT/CT imaging of Re-188-BMEDA-liposome in a C26 murine colon carcinoma solid tumor animal model
    作者: Chang, YJ;Chang, CH;Chang, TJ;Yu, CY;Chen, LC;Jan, ML;Luo, TY;Lee, TW;Ting, G
    贡献者: National Institute of Cancer Research
    摘要: Nanoliposomes are useful carriers in drug delivery. Radiolabeled nanoliposomes have potential applications in radiotherapy and diagnostic imaging. In this study, the biodistribution and pharmacokinetics of Re-188-BMEDA-labelled pegylated liposomes (RBLPL) and unencapsulated Re-188-BMEDA administered by the i.v. route in murine C26-colon tumour-bearing mice were investigated. MicroSPECT/CT images were performed to evaluate the distribution and tumor targeting of RBLPL in mice. For the biodistribution study, the highest uptake of liposome in tumors was 3.62% 0.73% at 24 h after RBLPL administration, and the tumor to muscle ratio of RBLPL was 7.1-fold higher than that of 188Re-BMEDA. With image analysis, the highest SUV in tumor was 2.81 +/- 0.26 at 24 h after injection of RBLPL. The Pearson correlation analysis showed a positive correlation of tumor targeting or uptake of RBLPL between biodistribution and microSPECT semi-quantification imaging analysis (r=0.633). The results of the pharmacokinetics revealed that the area under the tissue concentration-time curve (AUC) of RBLPL was 4.7-fold higher than that of unencapsulated Re-188-BMEDA. These results suggested the potential benefit and advantage of Re-188-labeled nanoliposomes for imaging and treatment of malignant diseases.
    关键词: Oncology
    日期: 2007-07
    關聯: Anticancer Research. 2007 Jul-Aug;27(4B):2217-2225.
    Link to: http://ar.iiarjournals.org/content/27/4B/2217.abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-7005&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000248545900014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34547773740
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