國家衛生研究院 NHRI:Item 3990099045/3074

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shiow-Ju Lee > Periodical Articles > Item 3990099045/3074

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3074

Title:	Secondary metabolites from the stem bark of Litsea akoensis and their cytotoxic activity
Authors:	Chang, SY;Cheng, MJ;Kuo, YH;Lee, SJ;Chang, HS;Chen, IS
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Six new butanolides, litseadioxanins A and B (1 and 2, resp.) bearing a 1,2-dioxane moiety, litseatrinolides A and B (3 and 4, resp.), and litseakolides D-1 and D-2 (5 and 6, resp.), were isolated from the stem bark of Litsea akoensis, together with six known compounds. The structures of the new compounds were characterized by in-depth NMR-spectroscopic and mass-spectrometric analyses. Butanolides 1-4, and a mixture of 6 and litsenolide E-2, and litsenolide B-1 were tested against human tumor cells, including MCF-7 (human breast adenocarcinoma), NCI-H460 (non-small-cell lung cancer), and SF-268 (glioblastoma) cell lines. Among the tested compounds, litsenolide B-1 exhibited marginal cytotoxic activity against MCF-7, NCI-H460, and SF-268 cell lines in vitro.
Keywords:	Chemistry, Multidisciplinary
Date:	2008
Relation:	Helvetica Chimica Acta. 2008;91(6):1156-1165.
Link to:	http://dx.doi.org/10.1002/hlca.200890125
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0018-019X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000257531400021
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=55549092107
Appears in Collections:	[Shiow-Ju Lee] Periodical Articles

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