國家衛生研究院 NHRI:Item 3990099045/3094
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    題名: Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors
    作者: Liou, JP;Wu, ZY;Kuo, CC;Chang, CY;Lu, PY;Chen, CM;Hsieh, HP;Chang, JY
    貢獻者: National Institute of Cancer Research;Division of Biotechnology and Pharmaceutical Research
    摘要: 1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC50 Of 0.9 and 0.6 mu M, respectively, exhibited antitubulin activity superior or comparable to that of colchicine and combretastatin A-4. They also showed antiproliferative activity with IC50 of 0.3-5.4 nM in a set of human cancer cell lines.
    關鍵詞: Chemistry, Medicinal
    日期: 2008-07-24
    關聯: Journal of Medicinal Chemistry. 2008 Jul;51(14):4351-4355.
    Link to: http://dx.doi.org/10.1021/jm800150d
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000257721600031
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=47749140369
    顯示於類別:[張俊彥] 期刊論文
    [謝興邦] 期刊論文
    [郭靜娟] 期刊論文

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