國家衛生研究院 NHRI:Item 3990099045/3109
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    題名: Associations of Mycobacterium tuberculosis genotypes with different ethnic and migratory populations in Taiwan
    作者: Dou, HY;Tseng, FC;Lu, JJ;Jou, R;Tsai, SF;Chang, JR;Lin, CW;Miu, WC;Su, IJ
    貢獻者: Division of Clinical Research;Division of Molecular and Genomic Medicine
    摘要: The distribution of human Mycobacterium tuberculosis (MTB) genotypes is reportedly associated with geography, ethnicity and population migrations. Three groups of 208 patients with tuberculosis in Taiwan were sampled to test this observation: (1) 41 aborigines of Austronesian ethnicity, who have been inhabiting in Taiwan for more than 500 years; (2) 58 veterans of Han Chinese origin, who moved as the first generation from Mainland China to Taiwan 55-60 years ago; and (3) 109 patients representing the general Taiwanese population of Han Chinese whose ancestors migrated to Taiwan around 200-400 years ago. A total of 208 MTB isolates, one per patient, were analyzed by spoligotyping and mycobacterial interspersed repetitive unit (MIRU) typing. Beijing ancient strains and Haarlem strains predominated among aborigines, while Beijing modern strains were common among veterans and the general population. All Beijing strains were further analyzed by typing the NTF loci and RD deletion. Results suggest a chronological trend among Beijing isolates from the three groups: isolates from the aborigines had signatures compatible with ancient lineages, and those from veterans and the general population were more contemporary. Our data indicate that the distribution of MTB genotypes/strains in Taiwan is associated with different populations whose migratory activities occurred between 55 and 500 years ago. These results suggest that transmission of mTB may have been relatively restricted to close contacts.
    關鍵詞: Infectious Diseases
    日期: 2008-05
    關聯: Infection Genetics and Evolution. 2008 May;8(3):323-330.
    Link to: http://dx.doi.org/10.1016/j.meegid.2008.02.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1567-1348&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000256289400011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=42649142898
    顯示於類別:[蘇益仁(2002-2015)] 期刊論文
    [蔡世峯] 期刊論文
    [曾凡真] 期刊論文
    [杜鴻運] 期刊論文

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