國家衛生研究院 NHRI:Item 3990099045/3110
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    题名: Suppression of p38 mitogen-activated protein kinase inhibits hepatitis B virus replication in human hepatoma cell: the antiviral role of nitric oxide
    作者: Chang, WW;Su, IJ;Lai, MD;Chang, WT;Huang, W;Lei, HY
    贡献者: Division of Clinical Research
    摘要: The role of the p38 mitogen-activated protein kinase (MAPK) pathway in hepatitis B virus (HBV) replication was investigated in this study. After transient transfection with HBV plasmid, p38 MAPK, but not JNK or ERK1/2, was significantly phosphorylated in human hepatoma cell Huh7. Interestingly, HBV proteins and RNA synthesis were significantly inhibited by a specific inhibitor of p38 MAPK, SB203580, in a dose-dependent manner. Intracellular core-associated DNA, extracellular virion-associated DNA and covalently closed circular DNA were also significantly inhibited by SB203580. Further results showed the antiviral role of nitric oxide (NO) on the suppression of HBV replication and downregulation of p38 MAPK phosphorylation. In conclusion, these results suggested that suppression of phosphorylation of p38 MAPK by inhibitor or NO could inhibit intracellular HBV replication.
    关键词: Gastroenterology & Hepatology;Infectious Diseases;Virology
    日期: 2008-07
    關聯: Journal of Viral Hepatitis. 2008 Jul;15(7):490-497.
    Link to: http://dx.doi.org/10.1111/j.1365-2893.2008.00968.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1352-0504&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000256494900003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=44849085529
    显示于类别:[蘇益仁(2002-2015)] 期刊論文

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