國家衛生研究院 NHRI:Item 3990099045/3225
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    题名: Pre-medication with intravenous clonidine suppresses fentanyl-induced cough
    作者: Horng, HC;Wong, CS;Hsiao, KN;Huh, BK;Kuo, CP;Cherng, CH;Wu, CT
    贡献者: Vaccine Research and Development Center
    摘要: Background: A reflex cough is often observed after an intravenous bolus of fentanyl. This study was conducted to determine whether pre-treatment with intravenous clonidine could effectively attenuate fentanyl-induced cough. Methods: Three hundred ASA I-II patients, aged between 18 and 80 years, undergoing various elective surgeries, were enrolled in this study. All patients were randomly assigned to one of two groups treated with intravenous clonidine 2 μg/kg (clonidine group) or the same volume of normal saline (control group). Intravenous fentanyl (2 μg/kg in 2 s) was injected 2 min after the clonidine or normal saline injection. Changes in the hemodynamics, auditory evoked potentials (AEPs) and Observer Assessment of Alertness/Sedation (OAA/S) rating scale were recorded before and 2 min after the clonidine or normal saline injection and 1 min after the fentanyl injection. The number of coughs 1 min after the fentanyl injection was also recorded. Results: Patients in the clonidine group showed a significantly lower incidence of cough than those in the control group (17.3% vs. 38.7%, respectively; P < 0.01). The blood pressure was lower in the clonidine group than in the control group. There were no significant differences in AEP or OAA/S rating scale. Conclusions: Pre-treatment with intravenous clonidine (2 μg/kg) suppressed the reflex cough induced by fentanyl, with mild hemodynamic changes. Therefore, intravenous clonidine may be a clinically useful method of suppressing fentanyl-induced cough.
    日期: 2007-08
    關聯: Acta Anaesthesiologica Scandinavica. 2007 Aug;51(7):862-865.
    Link to: http://dx.doi.org/10.1111/j.1399-6576.2007.01335.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0001-5172&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000248042800010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34447341977
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