國家衛生研究院 NHRI:Item 3990099045/3250
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    题名: Mesoporous silica nanoparticles as a delivery system of gadolinium for effective human stem cell tracking
    作者: Hsiao, JK;Tsai, CP;Chung, TH;Hung, Y;Yao, M;Liu, HM;Mou, CY;Yang, CS;Chen, YC;Huang, DM
    贡献者: Center for Nanomedicine Research
    摘要: The progress of using gadolinium (Gd)-based nanoparticles in cellular tracking lags behind that of superparamagnetic iron oxide (SPIO) nanoparticles in magnetic resonance imaging (MRI). Here, dual functional Gd-fluorescein isothiocyanate mesoporous silica nanoparticles (Gd-Dye@MSN) that possess green fluorescence and paramagnetism are developed in order to evaluate their potential as effective T1-enhancing trackers for human mesenchymal stem cells (hMSCs). hMSCs are labeled efficiently with Gd-Dye@MSN via endocytosis. Labeled hMSCs are unaffected in their viability, proliferation, and differentiation capacities into adipocytes, osteocytes, and chondrocytes, which can still be readily MRI detected. Imaging, with a clinical 1.5-T MRI system and a low incubation dosage of Gd, low detection cell numbers, and short incubation times is demonstrated on both loaded cells and hMSC-injected mouse brains. This study shows that the advantages of biocompatibility, durability, high internalizing efficiency, and pore architecture make MSNs an ideal vector of T1-agent for stem-cell tracking with MRI. ? 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
    日期: 2008-09
    關聯: Small. 2008 Sep;4(9):1445-1452.
    Link to: http://dx.doi.org/10.1002/smll.200701316
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1613-6810&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000259536800027
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52649172803
    显示于类别:[黃東明] 期刊論文
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