國家衛生研究院 NHRI:Item 3990099045/3260
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3260


    Title: Chronic treatment with aripiprazole induces differential gene expression in the rat frontal cortex
    Authors: Cheng, MC;Liao, DL;Hsiung, CA;Chen, CY;Liao, YC;Chen, CH
    Contributors: Division of Mental Health and Substance Abuse Research;Division of Biostatistics and Bioinformatics
    Abstract: Chronic treatment of antipsychotic drugs can modulate gene expression in the brain, which may underscore their clinical efficacy. Aripiprazole is the first approved antipsychotic drug of the class of dopamine D2 receptor partial agonist, which has been shown to have similar efficacy and favourable side-effects profile compared to other antipsychotic drugs. This study aimed to identify differential gene expression induced by chronic treatment of aripiprazole. We used microarray-based gene expression profiling technology, real-time quantitative PCR and Western blot analysis to identify differentially expressed genes in the frontal cortex of rats under 4 wk treatment of aripiprazole (10 mg/kg). We were able to detect ten up-regulated genes, including early growth response gene 1, 2, 4 (Egr1, Egr2, Egr4), chromobox homolog 7 (Cbx7), cannabinoid receptor (Cnr1), catechol-O- methyltransferase (Comt), protein phosphatase 2c, magnesium dependent (Ppm2c), tachykinin receptor 3 (Tacr3), Wiscott-Aldrich syndrome-like gene (Wasl) and DNA methyltransferase 3a (Dnmt3a). Our data indicate that chronic administration of aripiprazole can induce differential expression of genes involved in transcriptional regulation and chromatin remodelling and genes implicated in the pathogenesis of psychosis. ? 2007 Collegium Internationale Neuropsychopharmacologicum.
    Date: 2008-03
    Relation: International Journal of Neuropsychopharmacology. 2008 Mar;11(2):207-216.
    Link to: http://dx.doi.org/10.1017/s1461145707008048
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1461-1457&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000259199000006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38949120504
    Appears in Collections:[Chia-Hsiang Chen(2009-2013)] Periodical Articles
    [Chao A. Hsiung] Periodical Articles
    [Ding-Lieh Liao(2005-2008)] Periodical Articles
    [Yu-Chieh Liao] Periodical Articles

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