國家衛生研究院 NHRI:Item 3990099045/3261
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 914709      Online Users : 1406
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3261


    Title: Lack of evidence to support the glyoxalase 1 gene (GLO1) as a risk gene of autism in Han Chinese patients from Taiwan
    Other Titles: Lack of evidence to support the glyoxalase 1 gene (GL01) as a risk gene of autism in Han Chinese patients from Taiwan
    Authors: Wu, YY;Chien, WH;Huang, YS;Gau, SSF;Chen, CH
    Contributors: Division of Mental Health and Substance Abuse Research
    Abstract: Purpose: Previous studies have revealed inconsistent findings regarding the association between the glyoxalase 1 protein (GLO1) gene and autism. This study aimed to replicate the genetic association of the C419A of the GLO1 gene with autism and to perform mutation screening of all the exons of the GLO1 gene in a sample of Han Chinese patients with autism from Taiwan. Methods: The sample included 272 patients with autism and 310 healthy controls. All the exons and the promoter region of the GLO1 gene were PCR-amplified and sequenced for mutation screening and genotyping. Results: We did not find significant differences of allelic and genotypic frequency distributions of C419A between the autism and control groups. Moreover, we did not identify any other mutations in the exon regions associated with autism in this sample. We discovered two single nucleotide polymorphisms (SNPs) at the 5′ untranslated region of the GLO1 gene, designated g.-264T/G and g.-7T/C; however, these two SNPs were not associated with autism in this sample. Further analysis of halplotypes constructed from these 3 SNPs (g.-264T/G, g.-7T/C, and C419A) found no haplotype associated with autism. Our sample size has the power of 0.57 and 0.94 to detect a small effect (0.1) in the genotype and allele frequency distributions at the alpha level of 0.05, respectively. Conclusions: Our findings suggest that the GLO1 gene is unlikely a major susceptible gene for autism in an ethnic Chinese population from Taiwan. ? 2008 Elsevier Inc. All rights reserved.
    Date: 2008-10
    Relation: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2008 Oct;32(7):1740-1744.
    Link to: http://dx.doi.org/10.1016/j.pnpbp.2008.07.019
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0278-5846&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000259843500021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=51349106140
    Appears in Collections:[Chia-Hsiang Chen(2009-2013)] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    SCP51349106140.pdf179KbAdobe PDF849View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback