國家衛生研究院 NHRI:Item 3990099045/3274
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    题名: Association of Cytochrome P450 1B1 Gene Expression in Peripheral Leukocytes with Blood Lipid Levels in Waste Incinerator Workers
    作者: Hu, SW;Lin, P;Chen, CC
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Purpose: This study investigated whether CYP1B1 gene expression was associated with blood lipids levels. Methods: Workers from a municipal waste incineration plant in Taiwan participated in a questionnaire survey and physical examination and provided fasting blood samples for blood lipid analysis. CYP1B1 gene expression in workers' leukocytes was determined with the real-time reverse transcriptase polymerase chain reaction method, and 112 workers were categorized into three groups (low-, medium-, and high-expression) by their relative CYP1B1 gene expression levels. Multiple regression analyses were used to assess the association between blood lipid parameter and CYP1B1 expression. Results: High-density lipoprotein (HDL) cholesterol was significantly lower in the high CYP1B1 expression group than in the low- and medium-expression groups (parameter estimate [standard error] = -7.16 [2.42] and -7.02 [2.46] mg/dL, respectively), after controlling for age, sex, CYP1B1 genotype, duration of employment, current number of cigarettes smoked per day, current alcohol drinking status, and body mass index. Triglycerides, low-density lipoprotein (LDL), and total cholesterol were not significantly different among the CYP1B1 expression groups. Furthermore, workers carrying the CYP1B1*3 allele had significantly higher mean HDL, LDL, and total cholesterol, respectively, than those with CYP1B1*1/*1. Conclusions: CYP1B1 expression was associated with decreased HDL cholesterol levels in incinerator workers. 穢 2008 Elsevier Inc. All rights reserved.
    日期: 2008-10
    關聯: Annals of Epidemiology. 2008 Oct;18(10):784-791.
    Link to: http://dx.doi.org/10.1016/j.annepidem.2008.05.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1047-2797&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000260022200007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52249109811
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