國家衛生研究院 NHRI:Item 3990099045/3309
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    题名: Increased Risks of Congenital, Neurologic, and Endocrine Disorders Associated with Autism in Preschool Children: Cognitive Ability Differences
    作者: Chen, CY;Chen, KH;Liu, CY;Huang, SL;Lin, KM
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Objective: To investigate the increased risk of congenital, neurologic, and endocrine disorders in autistic preschool children and to probe possible cognitive impairment-associated variation in such risks. Study design: Using a population-based longitudinal study, a total of 3440 autistic children born in 1997-1999 and 33 391 age- and residential urbanicity-matched control subjects were identified from the National Health Insurance Research Database in Taiwan. Conditional logistic analyses were performed to estimate the strength of association stratified by the presence of cognitive impairment. Results: Autistic children were found to have greatly elevated risks of congenital anomalies (eg, tuberous sclerosis: adjusted odds ratio [aOR] = 34?61) and neurologic disorders (eg, epilepsy: aOR = 5?13) compared with their matched nonautistic peers. The increased risk of medical diseases for mentally retarded autism were approximately 1.6 to 9 times greater than those for isolated autism. Conclusions: The observed cognitive impairment-related variation in the increased risk of congenital, neurological, and endocrine disorders with autism may provide some clinical and etiologic implications that warrant investigation in the future. ?2009 Mosby, Inc. All rights reserved.
    日期: 2009-03
    關聯: Journal of Pediatrics. 2009 Mar;154(3):345-350.e341.
    Link to: http://dx.doi.org/10.1016/j.jpeds.2008.09.043
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3476&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000264166100011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=60549112736
    显示于类别:[林克明(2004-2009)] 期刊論文
    [陳娟瑜(2004-2010)] 期刊論文

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