國家衛生研究院 NHRI:Item 3990099045/3311
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3311


    Title: The coding-synonymous polymorphism rs1045280 (Ser280Ser) in Beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia
    Authors: Liou, YJ;Wang, YC;Chen, JY;Chen, ML;Chen, TT;Bai, YM;Lin, CC;Liao, DL;Lai, IC
    Contributors: Division of Mental Health and Substance Abuse Research
    Abstract: Background: Tardive dyskinesia (TD) is a severe and potentially irreversible adverse effect of long-term antipsychotic treatment. Typical antipsychotics are commonly binding to the dopamine receptor D2 (DRD2), but the occurrence of antipsychotic-induced TD is rather delayed; therefore, the development of TD may be associated with mediators or signalling complexes behind DRD2, such as ?-arrestin 2 (ARRB2), an important mediator between DRD2 and serine-threonine protein kinase (AKT) signal cascade. Methods: A case-control study to evaluate the association between rs1045280 (Ser280Ser) and antipsychotic-induced TD was performed amongst 381 patients (TD/non-TD = 228/153). Results: There was a significant difference in the genotype distribution between TD and non-TD groups (P = 0.025); furthermore, the allelic analysis indicated that patients with T allele had increased risk of TD occurrence (ORT = 1.58, 95% CI = 1.14-2.19, P = 0.007). Conclusions: To the best of our knowledge, this is the first study reporting a positive association between the SNP rs1045280 and TD in schizophrenic patients. ?2008 The Author(s).
    Date: 2008-12
    Relation: European Journal of Neurology. 2008 Dec;15(12):1406-1408.
    Link to: http://dx.doi.org/10.1111/j.1468-1331.2008.02316.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1351-5101&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000261056000033
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=56049113262
    Appears in Collections:[Ding-Lieh Liao(2005-2008)] Periodical Articles

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