國家衛生研究院 NHRI:Item 3990099045/3338
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    题名: Development of antiviral agents for enteroviruses
    作者: Chen, TC;Weng, KF;Chang, SC;Lin, JY;Huang, PN;Shih, SR
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Enteroviruses (EVs) are common human pathogens that are associated with numerous disease symptoms in many organ systems of the body. Although EV infections commonly cause mild or non-symptomatic illness, some of them are associated with severe diseases such as CNS complications. The current absence of effective vaccines for most viral infection and no available antiviral drugs for the treatment of EVs highlight the urgency and significance of developing antiviral agents. Several key steps in the viral life cycle are potential targets for blocking viral replication. This article reviews recent studies of antiviral developments for EVs based on various molecular targets that interrupt viral attachment, viral translation, polyprotein processing and RNA replication. The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
    日期: 2008-12
    關聯: Journal of Antimicrobial Chemotherapy. 2008 Dec;62(6):1169-1173.
    Link to: http://dx.doi.org/10.1093/jac/dkn424
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0305-7453&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000260975500001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=56649085335
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