國家衛生研究院 NHRI:Item 3990099045/3347
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    题名: Association study of HLA-A gene and schizophrenia in Han Chinese from Taiwan
    作者: Chao, YL;Shen, YC;Liao, DL;Chen, JY;Wang, YC;Lai, IC;Liou, YJ;Chen, CH
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Dysregulation of the immune response has been proposed as a precipitating factor of schizophrenia, and human leukocyte antigens (HLA) play a critical role in regulating the cascade of immunological reaction. Hence, many studies have investigated the relationship between the HLA system and schizophrenia. HLA is a complex gene family that contains several highly polymorphic genes, while the HLA-A gene is the most often studied gene to be associated with schizophrenia in the literature. A recent study reported that the interaction of the HLA-A10 allele and Chlamydial infection was highly associated with schizophrenia in a German population, which prompted us to investigate whether the HLA-A gene was also associated with schizophrenia in our population. Using a sequencing-based HLA typing method, we determined the HLA-A genotypes in 377 Han Chinese patients with schizophrenia (214 males, 163 females) and 321 non-psychotic Han Chinese control subjects (164 males, 157 females) from Taiwan. In total, 26 DNA-defined HLA-A alleles were identified in this sample. However, no significant differences of these allelic frequencies were found between the patients and the control subjects, suggesting that the HLA-A gene was unlikely a major risk factor of schizophrenia in this sample. As different populations have different HLA polymorphisms, an examination of the relationship of other HLA genes and schizophrenia in our population, with a larger sample size, is warranted in the future. 穢 2008 Elsevier Inc. All rights reserved.
    日期: 2008-12-12
    關聯: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2008 Dec 12;32(8):1834-1837.
    Link to: http://dx.doi.org/10.1016/j.pnpbp.2008.08.009
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0278-5846&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000261911900013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=56749183652
    显示于类别:[陳嘉祥(2009-2013)] 期刊論文
    [廖定烈(2005-2008)] 期刊論文

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